This interpretation would be merged with the meaning of the 2nd house—Security, possessions, what makes us feel safe. When Uranus moves into your 3rdhouse (in this example), it would be treated as if this was the second, but colored by the native meaning of the 3rd: communications, siblings, communication, and such.
Also read Uranus through the houses as he travels through your houses when they are in the natural order. Below, for example, When Uranus is in Leo, it would be read as traveling through the 9th house.
Uranus through the Houses in 7-year cycles:
Uranus transiting here brings in the start of news cycles. It heralds anything that has potential for renewal, rebirth, or creation. The changes that happen during this cycle lay a foundation for the rest of the seven–year cycles.
In the first house, Uranus asks us to explore our own creativity and move toward a fuller expression of our own totality and unique nature. It is a time of self–renewal. During this planet’s journey through your first house, you will most probably experience restlessness and discontent with status quo. This can be the impetus toward change.
You may experience inner struggles with the desire to hold onto the comfort of life as-is because it had offered you familiarity or security. And yet a deep part of yourself craves more freedom and change.
The effect of Uranus moving through your first house, can disrupt personal relationships. Others may not appreciate the changes in you or even become afraid of them. You may come to choice points where are you know that you must either give up long-held relationships that no longer harmonize with your changing inner self and desire to live in a different way, or keep the security you’re familiar with and suffer in silence.
If these changes aren’t keeping with your true self and your highest good, suppressing them will only result in the build up tension that could explode in rash decisions that disrupt your life in a possibly destructive way. It is better to find more congenial ways to embrace the changes that you are called to in a more peaceful way.
On the other hand, in cases such as leaving a traditional religion where family and friends are still entrenched in the beliefs and dogma of that religion. It can be difficult. It could result in anger, disappointments, fear, and outright hostility from your decision to follow your heart and move-on. In this case, you must deal with your own inner conflict about what Uranus is urging you to do and to heal your emotions concerning the separation from people and ideologies that no longer serve your highest good. In other words, it is useful to understand that how someone reacts to you changing has everything to do with them, and little or nothing to do with you. They lash out because of their own fears, or deep feelings. You have no responsibility to sacrifice your greater good to appease their inability to accept you as you are and not as what they want you to be.